The list of ingredients in their newer Focus+ stack, is quite familiar, featuring a significant number of well-researched nootropics, paired with an unknown (but observationally high) dose of stimulants and adaptogens. Read on to find out what our testers thought about it, and whether or not Focus+ is on par with the best nootropics.

Excelerol Focus Plus Label and Indgredients

The Ingredients

Vitamin B12 – 1,250

An essential vitamin B nutrient, B12 plays an important role in numerous bodily functions, including neurological function and development.

Niacin – 5 mg

This is a common B vitamin linked to both increased cognition and longevity, and niacin is responsible for the famous (and harmless) “flush” some users get when taking it.

Huperzine 1% Standardized – 12.5 mcg

Huperzine A is a compound derived from Chinese club moss that has been used to improve cognitive performance in patients with Alzheimer’s and vascular dementia.

Vinpocetine – 600 mcg

Vinpocetine is a chemical derived from the periwinkle plant, and it’s known to increase cerebral blood flow. Doctors in Hungary have been prescribing this compound to treat cerebrovascular disorders for decades.

Proprietary Formulation – 650 mg

Guarana Extract

Guarana is a climbing plant native to the Amazon with seeds that contain almost four times the amount of caffeine as coffee. Even in low doses, it often provides more stimulation than caffeine alone  due to its concentration of phytonutrients.

Kola Nut Extract

The fruit of the kola tree, the kola nut has been used as a flavoring ingredient in many consumer products. It contains both caffeine and theobromine, an alkaloid also found in the cacao plant.

DMAE

DMAE Bitrate, or Deanol, is a chemical used to treat ADHD, improve memory, and boost cognitive function. Deanol is essential to the production and of choline, one of the building blocks of the neurotransmitter acetylcholine. It’s a chemical precursor to choline and boosts alertness.

Acetyl L-Carnitine

This compound pairs very well with choline; when combined, the two form the neurotransmitter acetylcholine. Having both in the same supplement is a good hedge in case the body is deficient in either compound.

Bacopa Monnieri Extract

Bacopa Monnieri is an herb used as an antidepressant and a cognitive booster. While performing stressful cognitive tests, subjects taking Bacopa Monnieri experienced the herb’s nootropic effects and reduced both stress and cortisol levels.

Peppermint Oil

Often used as a flavoring agent, peppermint oil has also been used in the treatment of a variety of digestive problems. The smell of peppermint has been shown to enhance memory.

Tulsi (Holy Basil) Extract

A noted adaptogen, ursolic acid (the active ingredient in this extract) helps reduce the negative effects of stress. Note: In high dosages, research indicates ursolic acid may actually be an anti-fertility agent and could reduce reproductive capability in the short term. We’ve had good experience with adaptogens before, but wonder if it would have been a good idea to leave this ingredient out, given its potential side effects.

Ginkgo Biloba Extract

Ginko has been used in Chinese medicine  for thousands of years to promote memory. More recently, clinical studies and research reviews have pointed to its efficacy in fighting dementia and neural decline.

Rhodiola Extract

While there’s some evidence that Rhodiola Rosea can combat the effects of physical stress, it’s best known and well-researched to fight fatigue from mental challenges and tasks. Basically, evidence suggests this herb helps us better manage stress, and it also combats fatigue we might feel from mentally (and potentially physically) grueling tasks. Some early research also indicates Rhodiola could improve overall longevity and brain health  in mammals.

Phosphatidylserine

This is a widely-used nootropic compound that, until the 1990s, was very difficult to synthesize. Clinical testing and trials have linked it to improved cognition, and the compound has also been shown to reduce levels of cortisol (a well-known stress hormone).

L-Tyrosine

L-Tyrosine is linked to improving cognitive performance under conditions of stress, and the compound has been shown to actually reduce symptoms of stress itself, likely because it is involved in the production of dopamine.

Green Tea Extract, White Tea Extract, Black Tea Extract

All three of these teas contain varying quantities of polyphenols, caffeine, and l-theanine. An amino acid that’s becoming an increasingly common ingredient in nootropics, l-theanine promotes relaxation without being a sedative. Research suggests it also helps the brain deal with stress. Often paired with caffeine, l-theanine effects appear complementary to the world’s most popular stimulant. It may also increase brain activity and memory.

Alpha Glycerylphosphorylcholine (Alpha-GPC)

Choline is a vital compound in neurotransmission, and research suggests many Americans don’t get enough from their regular diets. (In fact, choline-based nootropics are increasingly common, and some of our testers have experienced enhanced memory and focus simply from supplementing choline.) This is the same form of choline as in popular stack (and BrainWiz tester favorite) Alpha Brain.

Citicoline

Choline is a vital compound in neurotransmission, and research suggests many Americans don’t get enough from their regular diets. (Choline-based nootropics are increasingly common, and some of our testers have experienced enhanced memory and focus simply from supplementing choline.) It’s a common ingredient in many nootropic stacks.

Other Ingredients: Glycerin, Hypromellose (Vegetarian), Titanium Dioxide, FD&C Blue #1, FD&C Yellow.

Usage Guidelines

Take 1 capsule daily with plenty of water.

What Our Testers Say

“I was excited to try this, since I had such a great experience with with the guarana in Lumonol.  Unfortunately, this wasn’t the case with Focus+.  I took 1 capsule, with breakfast, and two full glasses of water, but that was still not enough to deter the jitters. I felt a ton of nervous energy, and actually had a harder time concentrating than usual. This feeling lasted for about 4 hours, when I crashed hard.”

“I wasn’t too excited to try this product, especially because they did not have specifics on how much Holy Basil, or at what concentration, the ”˜Proprietary Formulation contained.’ I also didn’t know whether or not that formulation contained enough of an ingredient, say, Rhodiola, to meet the minimal effective dose. I tested it, though I was also hesitant because Ursolic Acid has some potential side effects. I took it in the morning, with with a shake, and felt a definite rush of energy. This was as effective as my pre-workout for energy, but I didn’t get much more out of it.”

“I felt a tad on edge on this supplement, whether I took it with or without coffee. There were no real cognitive benefits while taking this either.”

“As I have mentioned before, I do my best to avoid artificial coloring. I understand that this is part of their branding, each individual pill is blue and green with each capsule individually labeled, but I believe that a product can be just as recognizable for its quality as it is for its branding.  I do like this product as an energy supplement, but don’t think I would consider adding it to my permanent rotation even if Excelerol removed their overkill, on-pill branding. I prefer to get my jolt from coffee.”

BrainWiz Tips

• This stack contains several stimulant ingredients, loaded with caffeine. We suggest you take this supplement with food, and away from other caffeine-containing beverages, like coffee or tea.
• Make sure to drink plenty of water throughout the day, as this supplement can dehydrate you.
• Adaptogens like Rhodiola Rosea and Panax Ginseng may actually boost the effects of common stimulants like caffeine.
• As with any supplement or nutritional regimen, you should talk to your doctor or medical professional before use.
• The bottle suggests taking this supplement up to 3 times a day, but beware of taking it too late into the afternoon, especially if you have trouble falling asleep.

Supplement Summary

Focus+ may be a good alternative for non-coffee drinkers looking for a buzz, but for our testers, the benefits stopped there. Despite having an impressive list of ingredients, the fact that neither the quantities nor concentration of many ingredients listed makes us doubt there’s enough of them in the stack to really make a difference.

The post Energy That Comes Up Short? Reviewing Focus+ by Excelerol appeared first on Brain Wiz.

Holy Basil is an herb that’s been used for centuries in traditional ayurvetic medicine. It contains more than one active molecule, though some of its effects are likely tied to its high ursolic acid content. The compounds ocimarin and ocimumosides may account for much of the anti-stress or adaptogen effects. Holy Basil may also protect the liver against toxin damage, and like some other adaptogens, may help prevent cadmium accumulation/buildup within the body.

Ursolic acid has been linked to several side effects. Research indicates ursolic acid may actually be an anti-fertility agent and could reduce reproductive capability in the short term. Animal studies suggest it may inhibit spermatogenesis, though it has not been tied to long-term damage in the testes. It may also reduce sperm motility.

Optimal and effective dosages of Holy Basil, again, the main form of ursolic acid we’ve been seeing in nootropics, for humans are not presently known to a high degree of scientific accuracy, as most studies have been carried out on testing mice and rats.

As far as adaptogens go, most of the BrainWiz testers prefer Rhodiola rosea and Bacopa monnieri. Rhodiola especially has worked for us in several forms and stacks, and across research literature, relatively few side effects have been observed. (We take a closer look at Rhodiola and its relative lack of side effects here.)

If you experience any side effects from ursolic acid or Holy Basil extract, or if you have a condition that makes you especially sensitive to stimulants, impacts brain function, or causes adverse reactions to medications or supplements, it’s best to seek the advice of a medical professional before beginning any new supplement regime.

Image: By Mokkie (Own work) [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

The post What Are The Side Effects Of Ursolic Acid? appeared first on Brain Wiz.

MCT/medium chain triglyceride oil has come to prominence in recent years largely because of the exploding popularity of Bulletproof Coffee, and the sustained energy many users claims it gives them. Brain Awake also contains caffeine, and we wondered if the ingredient list would give a Bulletproof Coffee-like experience. We had our testers try Brain Awake to see if it gave a similar boost. Read below to see what we found out.

Brain Awake By Irwin Naturals Label & Ingredients

The Ingredients

• Vitamin B6 – 10 mg
  • Vitamin B6 is a water-soluble essential vitamin, involved in the production of neurotransmitters. Studies show that when taken in conjunction with Magnesium, B6 improved school attention in children diagnosed with ADHD.
• Vitamin B12 – 500 mcg
  • An essential vitamin B nutrient, B12 plays an important role in numerous bodily functions, including neurological function and development.
• Folate (as Quatrefolic) – 200 mcg
  • Another B vitamin linked to brain health and function.
• MCT (medium chain triglyceride) oil – 1000 mg
  • Medium chain triglycerides, normally in the form of refined coconut oils, have become very popular in recent years for numerous health benefits. They’re a primary ingredient in Bulletproof Coffee, and Bulletproof/Upgraded self claims they provide sustained energy to the brain without the crash of stimulants. Research indicates MCT oil creates more ketone bodies when metabolized than most other fats, and these ketone bodies can be quickly utilized by the brain for energy. Their consumption in place of other calories sources has also been linked to increase fat loss.
• Acetyl-L-Carnitine – 500 mg
  • This compound pairs very well with choline; when combined, the two form the neurotransmitter acetylcholine. Having both in the same supplement is a good hedge in case the body is deficient in either compound.
• Bacopa extract (50% bacosides)(whole plant) – 300 mg
  • Bacopa Monnieri is an herb used as an antidepressant and a cognitive booster. While performing stressful cognitive tests, subjects taking Bacopa Monnieri experienced the herb’s nootropic effects and reduced both stress and cortisol levels. This is actually the highest concentration of bacosides in the extract we’ve seen in a nootropic product.
• Holy Basil extract (2% ursolic acid) (leaf) – 200 mg
  • A noted adaptogen, Holy Basil extract helps reduce the negative effects of stress. Ursolic acid is one of several active compounds in Holy Basil, with others including ocimarin and the ocimumosides, two substances linked to adaptogenic effects. Note: In high dosages, research indicated ursolic acid may actually be an anti-fertility agent and could reduce reproductive capability in the short term. We’ve had good experience with adaptogens before, but wonder if it would have been a good idea to leave this one out given its potential side effects. We didn’t formulate this supplement, but generally our testers prefer adaptogens like Rhodiola rosea.
• AlphaWave L-Theanine – 100 mg
  • L-Theanine is an amino acid known to support a calm mood without inducing sleepiness. When used in conjunction with caffeine, it has been observed to reduce error rates while performing tasks.
• InnovaTea Natural tea Extract (standardized to 95% caffeine) – 52 mg
  • Caffeine is a stimulant acting on the central nervous system. One of the better-researched mental and physical performance enhancers, caffeine is proven to have acute effects on cognitive function and mood when used in conjunction with L-Theanine.
• Lemon Balm Extract – 30 mg
  • Also referred to as Melissa officinalis, lemon balm extract is linked to inducing calmness and boosting cognition, especially in stressful situations.
• Rosemary extract (3% rosmarinic acid) – 6 mg
  • The active compound in rosemary is Rosmarinic acid, a noted antioxidant and anti-inflammatory.
• Bioperine Complex – 6 mg
  • BioPerine is a common ingredient in Irwin Naturals products, as well as products from other general supplement manufacturers. Research suggests BioPerine/black pepper extract in the form of piperine helps the body more efficiently absorb a variety of nutrients through the digestive tract. If effective, it’s a good compliment to this supplement’s stack of nootropic ingredients.
• Other Ingredients: Flaxseed oil, gelatin, purified water, glycerin, beeswax, soy lecithin, St. John’s bread, silicon dioxide and titanium dioxide.

Usage Guidelines

Take three liquid soft-gels daily with a meal and a full glass of water. If caffeine keeps you up at night, do not take this product in the evening since it contains natural caffeine. Do not use if you may become pregnant, are pregnant or nursing. State of California Prop 65: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

What Our Testers Say

“I think the MCT oil gave me a physical boost as well as a mental boost, maybe even more of a physical kick. I felt the energy, but I think it was a shade less than I’ve had when drinking coffee with grassfed butter and MCT oil in the morning.”

“I cycle off and on Bulletproof Coffee, and I was hoping this would give me a similar kick. It did, but in a milder form. Also, one of the capsules must have popped during shipping, because when I opened my bottle everything was covered in a slimy brown film, and it made it difficult to swallow the pills. I’ll probably stick to Bulletproof Coffee if I want sustained energy for a long day or need to go longer than normal between meals.”

“This one caused some nausea for me (I usually take my supplements in the morning on an empty stomach and eat once I get to work). I wasn’t expecting this; I normally have an iron stomach. It gave me more energy throughout the day, but it’s a serving I’d have to time better in the future and plan my morning around.”

“I enjoyed the energy from this supplement, paired with a light breakfast, I felt like I could go until the late afternoon without needing a significant food break. I felt clear headed throughout that time, though I don’t think I was tons more productive than normal.”

BrainWiz Tips

• Take with a full glass of water and/or meal to avoid any stomach cramps; this is often true of MCT or fish oil-containing supplements.
• People have varying sensitivity to MCT oil; if you’ve never tried it before, it might be best to start with a smaller dosage to gauge your digestive system’s response.
• As with any supplement regime, it’s a good idea to talk to your healthcare provider before making any changes. This supplement contains an ingredient that’s been associated with reduced sperm fertility in males.

Supplement Summary

Brain Awake did have a similar effect to Bulletproof Coffee, but it wasn’t quite as pronounced, and the focus our testers felt wasn’t nearly as sharp as other supplements in recent memory. We’d suggest gauging your tolerance for MCT oil carefully from the start to avoid digestive issues. The inclusion of Holy Basil extract as the adaptogen of choice also has us scratching our heads a little bit, as there are similarly effective choices in existence without the same potential side effects.

If you like the effects of Bulletproof Coffee but aren’t a coffee drinker, Brain Awake is a zero-prep-required substitute. Overall, our testers reached for other supplements after their trial of Brain Awake was over.

The post Bulletproof Coffee’s Effect In A Pill? Reviewing Brain Awake By Irwin Naturals appeared first on Brain Wiz.